تولید و کنترل کیفی رادیوداروی 111Inپنتتروتاید در ایران

نوع مقاله: مقاله پژوهشی

نویسندگان

پژوهشکده‌ی کاربرد پرتوها، پژوهشگاه علوم و فنون هسته‌ای، سازمان انرژی اتمی

چکیده

رادیوداروی 111In- پنتتروتاید (اُکترواسکن) هم­‌اکنون به صورت گسترده در تشخیص انواع سرطان‌­ها در علم پزشکی کاربرد دارد. اکتروتاید دارویی با ساختاری مشابه سوماتواستاتین است که در حالت نشاندار شده با هسته­‌ی پرتوزای 111In به صورت وریدی تزریق می­‌شود. این رادیودارو با اتصال به گیرنده‌­های سوماتواستاتین به شکل یک عامل ترانوستیک عمل
می‌­کند. در دهه­‌ی اخیر 111Inپنتتروتاید به عنوان داروی تشخیص سینتیگرافی و تعیین پیشرفت تومورهای اولیه و متاستاتیک نورواندوکراین بیش­ترین مصرف را داشته است. در این مطالعه، کاربردهای این رادیودارو به همراه استراتژی‌­های تولید و کنترل کیفی به طور دقیق بررسی شد. به طور خلاصه، بهره­‌ی نشان‌دارسازی 111In- پنتتروتاید قبل از استفاده بر روی حیوانات جونده محاسبه شد. اتصال هسته­‌ی پرتوزای با تکنیک RTLC و خلوص رادیوشیمیایی با تکنیک HPLC اندازه­‌گیری شد. به سبب بالا بودن ثابت پایداری ترمودینامیکی DTPA و 3+In، بهره­‌ی تشکیل 111In- پنتتروتاید تحت شرایط به کار رفته در این پژوهش بالا بود.

کلیدواژه‌ها


عنوان مقاله [English]

Production and Quality Control of Indium-111 Pentetreotide Radiopharmaceutical in Iran

نویسندگان [English]

  • S. Y Fazaeli Hoseini Nezhad
  • M Erfani
چکیده [English]

111In pentetreotide (OctreoScanTM) radiopharmaceutical is used extensively for the detection of a variety of cancers in medicine. Octerotide is a pharmaceutical with a structure similar to somatostatin which is administrated via intravenous injection in an 111In labeled form. This radiopharmaceutical acts as a theranostic agent with binding to somatostatin receptors. Over the last decade, 111In pentetreotide has remained the most widely used radiopharmaceutical for the scintigraphic detection and staging of primary and metastatic neuroendocrine tumors. In this study, application of this radiopharmaceutical as well as the production and quality control strategies was investigated precisely. Briefly, the labeling yield of 111In pentetreotide was determined before the administration to the rodents. The incorporation of the radionuclide was measured by RTLC and the radiochemical purity was measured by HPLC. Due to the high thermodynamic stability constants for DTPA and In3+, the formation yield of 111In pentetreotide under the terms applied in this study was found to be high.

کلیدواژه‌ها [English]

  • 111In Pentetreotide
  • Somatostatin
  • Theranostic Agent
  • Neuroendocrine Tumors
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